Electrophysiology studies in man have demonstrated that bisoprolol fumarate significantly decreases heart rate, increases sinus node recovery time, prolongs AV node refractory periods, and, with rapid atrial stimulation, prolongs AV nodal conduction. Diaβeta is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. IV fluids and vasopressors should be administered. Intravenous glucagon may be useful. Maxide triamterene and hydrochlorothiazide is a combination of a -conserving diuretic and a natriuretic agent and is prescribed as a treatment for hypertension and edema. Maxide is also a diuretic given to patients who cannot risk low blood potassium. Maxide may be used alone or in combination with other antihypertensive drugs, such as beta-blockers but dosages may need to be adjusted; regardless, potassium levels in patients is recommended for all patients taking Maxide. Maxide is available in generic form. Common side effects of Maxide include dizziness, lightheadedness, headache, or upset stomach as your body adjusts to the medication. ditropan
This list is not complete and there may be other drugs that can interact with bisoprolol. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. In elderly patients, debilitated or malnourished patients, and patients with impaired renal or hepatic function, the initial and maintenance dosing should be conservative to avoid hypoglycemic reactions. See Section. The latter consist of those few that are truly idiosyncratic in nature or those that occur with such low frequency that a dose relationship may be difficult to discern. Therapy with a combination of bisoprolol and hydrochlorothiazide will be associated with both sets of dose-independent adverse effects, and to minimize these, it may be appropriate to begin combination therapy only after a patient has failed to achieve the desired effect with monotherapy.
Possible interactions between glyburide and coumarin derivatives have been reported that may either potentiate or weaken the effects of coumarin derivatives. The mechanism of these interactions is not known. Beta 1-selectivity of ZEBETA has been demonstrated in both animal and human studies. Once-daily dosing with bisoprolol fumarate results in less than two-fold intersubject variation in peak plasma concentrations. SPECIAL SENSES: Abnormal vision. Approximately 3 billion tablets sold in more than 76 Countries every year.
Hypoglycemia: See and Sections. Zebeta is a beta 1-selective cardioselective adrenoceptor blocking agent without significant membrane stabilizing activity or intrinsic sympathomimetic activity in its therapeutic dosage range. The maximal effect occurred within 1-4 hours post-dosing. What brand names are available for bisoprolol? Whether this interaction also occurs with the intravenous, topical or vaginal preparations of miconazole is not known.
Inactive ingredients: candelilla wax, crospovidone, hydroxypropyl cellulose, hypromellose, iron oxide red, iron oxide yellow, lactose, magnesium carbonate, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Drugs. After oral administration of hydrochlorothiazide, diuresis begins within 2 hours, peaks in about 4 hours, and lasts about 6 to 12 hours. Use of quinapril with a thiazide diuretic gives blood pressure lowering effect greater than that seen with either agent alone. CARDIOVASCULAR SYSTEM: Bradycardia, cor pulmonale, vasculitis, and deep thrombosis. Beta-blockers can precipitate or aggravate symptoms of arterial insufficiency in patients with peripheral vascular disease. Caution should be exercised in such individuals. These considerations may guide selection of therapy. MRHD on the basis of body weight and body surface area, respectively. Alcohol, barbiturates, or narcotics - potentiation of orthostatic hypotension may occur. The effectiveness of any oral hypoglycemic drug, including Diaβeta, in lowering blood glucose to a desired level decreases in many patients over a period of time, which may be due to progression of the severity of the diabetes or to diminished responsiveness to the drug. This phenomenon is known as secondary failure, to distinguish it from primary failure in which the drug is ineffective in an individual patient when first given. L occurred in approximately 2% of patients receiving quinapril. In most cases, elevated serum potassium levels were isolated values which resolved despite continued therapy. All informations on this page are taken from public sources such as search engines yahoo. In patients at risk of excessive hypotension, therapy with Accuretic should be started under close medical supervision. Such patients should be followed closely for the first 2 weeks of treatment and whenever the dosage of quinapril or diuretic is increased. Similar considerations may apply to patients with ischemic heart or cerebrovascular disease in whom an excessive fall in blood pressure could result in myocardial infarction or cerebrovascular accident.
Neither quinapril nor quinaprilat were mutagenic in the Ames bacterial assay with or without metabolic activation. Quinapril was also negative in the following genetic toxicology studies: in vitro mammalian cell point mutation, sister chromatid exchange in cultured mammalian cells, micronucleus test with mice, in vitro chromosome aberration with V79 cultured lung cells, and in an in vivo cytogenetic study with rat bone marrow. Cefixime is a broad spectrum cephalosporin antibiotic and is commonly used to treat bacterial infections of the ear, urinary tract, and upper respiratory tract. Hydrochlorothiazide, a sulfonamide, can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma. Symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation. Untreated acute angle-closure glaucoma can lead to permanent vision loss. The primary treatment is to discontinue hydrochlorothiazide as rapidly as possible. Prompt medical or surgical treatments may need to be considered if the intraocular pressure remains uncontrolled. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. Zebeta had minimal effect on serum lipids during antihypertensive studies. Accuretic should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma. Also, since the metabolism of quinapril to quinaprilat is normally dependent upon hepatic esterases, patients with impaired liver function could develop markedly elevated plasma levels of quinapril. No normal pharmacokinetic studies have been carried out in hypertensive patients with impaired liver function. Learn about the prescription medication Solodyn Minocycline Hydrochloride drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Beta-adrenergic blockade may mask clinical signs of hyperthyroidism, such as tachycardia. Abrupt withdrawal of beta-blockade may be followed by an exacerbation of the symptoms of hyperthyroidism or may precipitate thyroid storm. Hypokalemia may develop, especially with brisk diuresis when severe cirrhosis is present, during concomitant use of corticosteroids or adrenocorticotropic hormone ACTH or after prolonged therapy. Interference with adequate oral electrolyte intake will also contribute to hypokalemia. Hypokalemia and hypomagnesemia can provoke ventricular arrhythmias or sensitize or exaggerate the response of the heart to the toxic effects of digitalis. Hypokalemia may be avoided or treated by potassium supplementation or increased intake of potassium-rich foods. What should I avoid while taking bisoprolol Zebeta? MRHD. The mutagenic potential of bisoprolol fumarate was evaluated in the microbial mutagenicity Ames test, the point mutation and chromosome aberration assays in Chinese hamster V79 cells, the unscheduled DNA synthesis test, the micronucleus test in mice, and the cytogenetics assay in rats. There was no evidence of mutagenic potential in these in vitro and in vivo assays. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Do not stop taking it without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped. Your dose may need to be gradually decreased. rifadin
The presence of other medical problems may affect the use of ritodrine. Beta-adrenergic blockade may mask clinical signs of hyperthyroidism, such as tachycardia. These studies uncovered no evidence of a carcinogenic potential of hydrochlorothiazide in rats or female mice, but there was "equivocal" evidence of hepatocarcinogenicity in male mice. Hydrochlorothiazide was not genotoxic in in vitro assays using strains TA 98, TA 100, TA 1535, TA 1537, and TA 1538 of Salmonella typhimurium the Ames test; in the Chinese hamster ovary CHO test for chromosomal aberrations; or in vivo assays using mouse germinal cell chromosomes, Chinese hamster bone marrow chromosomes, and the Drosophila sex-linked recessive lethal trait gene. Avoid drinking alcohol. It can increase some of the side effects of bisoprolol. National Library of Medicine and Drugs. Dispense in a tight container. buy zantac vegas zantac
Zebeta bisoprolol fumarate has also been given concomitantly with thiazide diuretics. Bisoprolol fumarate alone or in combination with HCTZ has not been studied in nursing mothers. Thiazides are excreted in human breast milk. Take bisoprolol exactly as it was prescribed for you. Do not take the medication in larger amounts or for longer than recommended by your doctor. Follow the directions on your prescription label. Keep out of the reach of children. In elderly, debilitated, or malnourished patients, or in patients with renal or hepatic insufficiency, the initial dosing, dose increments, and maintenance dosage should be conservative to avoid hypoglycemic reactions. Hypoglycemia may be difficult to recognize in the elderly and in people who are taking beta-adrenergic blocking drugs or other sympatholytic agents. There are limited data on overdose with bisoprolol fumarate and hydrochlorothiazide. However, several cases of overdose with bisoprolol fumarate have been reported maximum: 2000 mg. Bisoprolol fumarate and HCTZ have been used individually and in combination for the treatment of hypertension. Patients with normal serum potassium at baseline. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. where to buy tacrolimus over the counter in canada
Gastrointestinal Reactions: Cholestatic jaundice and hepatitis may occur rarely which may progress to liver failure; Diaβeta should be discontinued if this occurs. Liver function abnormalities, including isolated transaminase elevations, have been reported. Administration of 10 to 80 mg of quinapril to patients with mild to severe hypertension results in a reduction of sitting and standing blood pressure to about the same extent with minimal effect on heart rate. Transient blurred vision, xanthopsia. Such patients may be unresponsive to the usual doses of used to treat allergic reactions. Store bisoprolol at room temperature away from moisture and heat. Anaphylactoid reactions have been reported in patients dialyzed with high-flux membranes and treated concomitantly with an ACE inhibitor. Anaphylactoid reactions have also been reported in patients undergoing low-density lipoprotein apheresis with dextran sulfate absorption. Removal of angiotensin II negative feedback on renin secretion leads to increased plasma renin activity PRA. As with other beta-blockers, ANA conversions have also been reported on bisoprolol fumarate. About 15% of patients in long-term studies converted to a positive titer, although about one-third of these patients subsequently reconverted to a negative titer while on continued therapy. Bisoprolol is used to treat hypertension high blood pressure. The risks of hypoglycemia, its symptoms and treatment, and conditions that predispose to its development should be explained to patients and responsible family members. Primary and secondary failure should also be explained. The most prominent effect of Zebeta is the negative chronotropic effect, resulting in a reduction in resting and exercise heart rate. There is a fall in resting and exercise cardiac output with little observed change in stroke volume, and only a small increase in right atrial pressure, or pulmonary capillary wedge pressure at rest or during exercise. Do not consider Communities as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. Removal of quinapril, which crosses the placenta, from the neonatal circulation is not significantly accelerated by these means. Although no dose response study was conducted in elderly patients, there was a tendency for older patients to be maintained on higher doses of bisoprolol fumarate. abow.info clavaseptin
Patients should be carefully monitored and treated with isoproterenol infusion or transvenous cardiac pacemaker insertion, as appropriate. Diminution of tonic sympathetic outflow from the centers in the brain. Fever, combined with aching and sore throat, laryngospasm, respiratory distress. Positive test results were also obtained in the Aspergillus nidulans non-disjunction assay, using an unspecified concentration of hydrochlorothiazide. If continue or become severe, tell your doctor promptly. Elderly patients are particularly susceptible to hypoglycemic action of glucose-lowering drugs. Hypoglycemia may be difficult to recognize in the elderly see . The initial and maintenance dosing should be conservative to avoid hypoglycemic reactions. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Exacerbations of angina pectoris and, in some instances, myocardial infarction or ventricular arrhythmia, have been observed in patients with coronary artery disease following abrupt cessation of therapy with beta-blockers. Calcium excretion is decreased by thiazides, and pathologic changes in the parathyroid glands, with hypercalcemia and hypophosphatemia, have been observed in a few patients on prolonged thiazide therapy. In Study A, doses of 5, 10, and 20 mg bisoprolol fumarate were administered for 4 weeks. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. It is a white crystalline powder which is approximately equally hydrophilic and lipophilic, and is readily soluble in water, methanol, ethanol, and chloroform. What is the most important information I should know about bisoprolol Zebeta? The pharmacokinetic profile of bisoprolol fumarate has been examined following single doses and at steady state. Binding to serum proteins is approximately 30%. Bisoprolol can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or tells you to do so. Swallow the whole or split tablet without crushing or chewing. Your diabetes medication or diet may need to be adjusted. The fetotoxicity in rats occurred at 125 times the MRHD on a body weight basis and 26 times the MRHD on the basis of body surface area. The maternotoxicity occurred at 375 times the MRHD on a body weight basis and 77 times the MRHD on the basis of body surface area. Sporadic liver test abnormalities have been reported. Discuss the risks and benefits with your doctor. If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. ZEBETA. However, initial dose modification is generally not necessary. The combination may be substituted for the titrated individual components. In clinical trials worldwide, or in postmarketing experience, a variety of other AEs, in addition to those listed above, have been reported. While in many cases it is not known whether a causal relationship exists between bisoprolol and these AEs, they are listed to alert the physician to a possible relationship. Purpura, photosensitivity, rash, urticaria, necrotizing angiitis vasculitis and cutaneous vasculitis fever, respiratory distress including pneumonitis and pulmonary edema, anaphylactic reactions. Both digitalis glycosides and beta-blockers slow conduction and decrease heart rate. Labas padidejo limfmazgiai labai daug ir visokio dydzio ant kirksnies, bei pazasties randu jau apie tris savaites nors nezine Kiek Jie laiko yra. These may be transient and may disappear despite continued use of Diaβeta. Bullous reactions, erythema multiforme, and exfoliative dermatitis, have been reported. If skin reactions persist, the drug should be discontinued. rabeprazole 10 mg
Periodic glycosylated hemoglobin determinations should be performed. FDA pregnancy category C. It is not known whether bisoprolol is harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. The FDA approved bisoprolol in July 1992. Kamagra Tablets. Kamagra tablets 100mg are used to treat erectile dysfunction impotence in men. The dose of Zebeta must be individualized to the needs of the patient. The usual starting dose is 5 mg once daily. It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk caution should be exercised when bisoprolol fumarate is administered to nursing women. These conditions should be treated with insulin. Warning signs or symptoms of fluid and electrolyte imbalance include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. zebeta stock price morningstar
Observed reductions in heart rate were slightly greater in the elderly than in the young and tended to increase with increasing dose. In general, no disparity in adverse experience reports or dropouts for safety reasons was observed between older and younger patients. Dose adjustment based on age is not necessary. Hemodialysis and peritoneal dialysis have little effect on the elimination of quinapril and quinaprilat. Multiple dose therapy with propranolol or cimetidine has no effect on the pharmacokinetics of single doses of quinapril. Some placental passage occurred when quinapril was administered to pregnant rats. Studies in rats indicate that quinapril and its metabolites do not cross the blood-brain barrier. Hydrochlorothiazide crosses the placenta freely but not the blood-brain barrier. Sexual dysfunction, renal failure, renal dysfunction, interstitial nephritis. ZEBETA should not be combined with other beta-blocking agents. In clinical trials, the most frequently reported laboratory change was an increase in serum triglycerides, but this was not a consistent finding. What should I discuss with my healthcare provider before taking bisoprolol Zebeta? Himalaya Healthcare Ltd: SKU: HIM213: Weight: 100. To retain relative selectivity, it is important to use the lowest effective dose. Because quinapril and hydrochlorothiazide are secreted in human milk, caution should be exercised when Accuretic is administered to a nursing woman. See Section for patients at increased risk. Failure to follow an appropriate dosage regimen may precipitate hypoglycemia. Patients who do not adhere to their prescribed dietary and drug regimen are more prone to exhibit unsatisfactory response to therapy. Even in patients without overt coronary artery disease, it may be advisable to taper therapy with Zebeta over approximately one week with the patient under careful observation. If withdrawal symptoms occur, Zebeta therapy should be reinstituted, at least temporarily. If any of these effects persist or worsen, tell your doctor or promptly. To be sure this medication is helping your condition, your blood pressure will need to be checked on a regular basis. Do not miss any scheduled appointments. generic buspar order shopping usa
They tend to be dose-related and may disappear when dosage is reduced. Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Accuretic as soon as possible. These adverse outcomes are usually associated with use of these drugs in the second and third trimester of pregnancy. Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. Appropriate management of maternal hypertension during pregnancy is important to optimize outcomes for both mother and fetus. The following information includes only the average doses of ritodrine. If your dose is different, do not change it unless your doctor tells you to do so. The injection form of this medicine will be given to you by your health care professional. Talk with your doctor about making changes to your lifestyle that may help this medication work better such as stress reduction programs, exercise, and dietary changes. The mechanism for this interaction is not known. No teratogenic effects of quinapril were seen in studies of pregnant rats and rabbits. Take this medication with a full glass of water. Patients subject to spontaneous hypoglycemia or diabetic patients receiving insulin or oral hypoglycemic agents, should be cautioned that beta-blockers may mask some of the manifestations of hypoglycemia, particularly tachycardia, and bisoprolol fumarate should be used with caution. nitrofurantoin
Zebeta has been used in elderly patients with hypertension. Fatigue, asthenia, chest pain, malaise, edema, weight gain, angioedema. The molecular weight is 493. Two patients undergoing desensitizing treatment with Hymenoptera venom while receiving ACE inhibitors sustained life-threatening anaphylactoid reactions. In the same patients, these reactions were avoided when ACE inhibitors were temporarily withheld, but they reappeared upon inadvertent challenge. Adults: In the first twenty-four hours after the doctor stops your intravenous ritodrine, your dose may be as high as 40 milligrams mg every eight hours. After that, the dose is usually 40 mg taken every eight to twelve hours. Your doctor may want you to take oral ritodrine up until it is time for you to deliver your baby or until your 37th week of pregnancy.
Diaβeta may increase cyclosporine plasma concentration and potentially lead to its increased toxicity. Monitoring and dosage adjustment of cyclosporine are therefore recommended when both drugs are coadministered. SKIN AND APPENDAGES: Urticaria, macropapular rash, and petechiases. Tablet - Strip of 10 Tablets online at 1mg. The hydrochlorothiazide component of Accuretic may decrease serum PBI levels without signs of thyroid disturbance. Another ACE inhibitor, captopril, has been shown to cause agranulocytosis and bone marrow depression rarely in patients with uncomplicated hypertension, but more frequently in patients with renal impairment, especially if they also have a collagen vascular disease, such as systemic lupus erythematosus or scleroderma. Agranulocytosis did occur during quinapril treatment in one patient with a history of neutropenia during previous captopril therapy. Available data from clinical trials of quinapril are insufficient to show that, in patients without prior reactions to other ACE inhibitors, quinapril does not cause agranulocytosis at similar rates. It is not known whether bisoprolol passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. The oculomucocutaneous syndrome associated with the beta-blocker practolol has not been reported with bisoprolol fumarate during investigational use or extensive foreign marketing experience. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. What is bisoprolol, and how does it work mechanism of action? Store away from heat and direct light. Electrophysiology studies in man have demonstrated that Zebeta significantly decreases heart rate, increases sinus node recovery time, prolongs AV node refractory periods, and, with rapid atrial stimulation, prolongs AV nodal conduction. cheapest dipyridamole order now shop
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Hydrochlorothiazide is well absorbed 65%-75% following oral administration. Absorption of hydrochlorothiazide is reduced in patients with congestive heart failure. Bisoprolol fumarate has a molecular weight of 766. These medicines are often given together to the mother to help her baby's lungs develop. If you are taking corticosteroids, your dose may need to be changed if ritodrine is also taken or injected. Sometimes the combination of these medicines increases the chance of side effects occurring in the mother.
PD 220" on one side. Close monitoring should continue until the physician is assured that the patient is out of danger. Severe hypoglycemic reactions with coma, seizure, or other neurological impairment occur infrequently, but constitute medical emergencies requiring immediate hospitalization. If hypoglycemic coma is diagnosed or suspected, the patient should be given a rapid intravenous injection of concentrated 50% glucose solution. As with other beta-blockers, conversions have also been reported on bisoprolol fumarate. Although it is not known whether Diaβeta is excreted in human milk, some sulfonylureas are known to be excreted in human milk. Because the potential for hypoglycemia in nursing infants may exist, a decision should be made whether to discontinue nursing or to discontinue administering the drug, taking into account the importance of the drug to the mother. If Diaβeta is discontinued and if diet alone is inadequate for controlling blood glucose, insulin therapy should be considered.
S- enantiomer is responsible for most of the beta-blocking activity. Asthma, bronchospasm, bronchitis, dyspnea, pharyngitis, rhinitis, sinusitis, URI upper respiratory infection. Binding to serum proteins has been reported to be approximately 40% to 68%. The plasma elimination half-life has been reported to be 6-15 hours. Hydrochlorothiazide is eliminated primarily by renal pathways. This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.
Hydrochlorothiazide is a benzothiadiazine diuretic. Thiazides affect renal tubular mechanisms of electrolyte reabsorption and increase excretion of sodium and chloride in approximately equivalent amounts. Natriuresis causes a secondary loss of potassium. Inactive ingredients include Colloidal Silicon Dioxide, Corn Starch, Crospovidone, Dibasic Calcium Phosphate, Hypromellose, Magnesium Stearate, Microcrystalline Cellulose, Polyethylene Glycol, Polysorbate 80, and Titanium Dioxide. The 5 mg tablets also contain Red and Yellow Iron Oxide. ADH. Diaβeta can cause weight gain.